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Generic brand of metformin (Novartis), as well a range of other prescription medications. But the study also shows that many people with the condition are also taking vitamins, and it urges doctors to question all patients about whether they also take medicines for heart disease and high blood pressure. If so, that could be "a red flag," the study says. "Vitamin and mineral supplements have long been held as a potential treatment for patients with coronary artery disease," says lead study author Brian J. K. Nargund, chief of heart disease at the University of California, San Francisco, and at the Francisco Veterans Affairs Medical Center, who worked as a public health researcher in Switzerland. But it's now clear that many of these supplements contain potentially high levels of metals, he adds. "It's a clear and present danger." And the problem isn't just for adults. "The children and adults who are taking these supplements in a vulnerable position," says lead investigator David A. Abrams, a professor of molecular pharmacology and physiology at the University of Pittsburgh, Pennsylvania, who also studies metabolic diseases. Many individuals with diabetes and hypertension also take metformin because it is considered to be a type 2 diabetes drug. recent meta-analysis found that metformin has a similar blood-pressure lowering effect — reducing systolic blood pressure by up to 7.3 millimeters of mercury (µL) compared with a placebo — as the blood-pressure drug warfarin. There's also evidence that this drug may help protect the heart from atherosclerosis. But newer use of the drug has led to an increasing number of people in cardiovascular disease. By 2014, about 9 percent of adults took metformin, more than double the percentage in 2002. And the researchers also found that most metformin prescriptions were written by physicians. In fact, some studies have also linked this practice in the United States, where prescription drug spending is nearly four times that of other western nations, to higher drug costs. "There is clear evidence that this a problem is on the rise," Abrams says. This is not the first time Nargund has studied vitamin and heart disease. Last year, for example, researchers in Europe reported that people who took vitamin C — either as a supplement or part of multivitamin — were more than twice as likely to develop a heart attack or stroke compared with people who didn't eat a regular diet rich in fruit and vegetables. They also found that those with the highest levels of vitamin C had a significantly lower risk of cardiovascular events. But Nargund says this study suggests that vitamin C, rather than supplements, may be responsible for this effect. The new study examined records from more than 13,000 men and women, followed for 22 years. They were given a physical and cognitive battery, including a battery of measurements their Cheapest brand viagra online blood pressure and heart rate, when they entered the study in 1977. 2001, they were aged 50-79. When does pioglitazone go generic In 2005, after several years of follow-up, they were asked about whether have been taking a prescription drug for heart disease, or a supplement containing vitamin C. Of those, 3,670 died from heart disease or stroke, with 6,908 participants who were taking prescription medications for heart disease and 5,770 taking vitamins. As part of the study, participants answered questions about their dietary habits, including whether they ate more than the average American or more than half of their food from plants or animals. They also answered questions about whether they took supplements containing vitamin C or a drug to lower blood pressure, like the blood-pressure drug warfarin. By 2010, nearly 22 percent of those taking the supplements also had been taking warfarin. In contrast, 9 percent of those taking the medications also took vitamin C This may be because the effects of vitamin C on lowering blood pressure.

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